Normalization Method for Transcriptional Studies of Heterogeneous Samples - Simultaneous Array Normalization and Identification of Equivalent Expression

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15 صفحه اول

A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis.

An intuitive normalization and gene identification method is proposed. After segmentation of the entire expression range into intensity intervals, the mean and standard deviation of the logarithm of expression ratios are calculated for each interval using the nearest neighbor genes. Genes with high differential expression are excluded from these calculations. For glass arrays, normalization is ...

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ژورنال

عنوان ژورنال: Statistical Applications in Genetics and Molecular Biology

سال: 2009

ISSN: 1544-6115

DOI: 10.2202/1544-6115.1339